Optimization of radiation therapy techniques for prostate cancer with prostate-rectum spacers: a systematic review

Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):278-88. doi: 10.1016/j.ijrobp.2014.06.044.


Dose-escalated radiation therapy for localized prostate cancer improves disease control but is also associated with worse rectal toxicity. A spacer placed between the prostate and rectum can be used to displace the anterior rectal wall outside of the high-dose radiation regions and potentially minimize radiation-induced rectal toxicity. This systematic review focuses on the published data regarding the different types of commercially available prostate-rectum spacers. Dosimetric results and preliminary clinical data using prostate-rectum spacers in patients with localized prostate cancer treated by curative radiation therapy are compared and discussed.

Publication types

  • Comparative Study
  • Review
  • Systematic Review

MeSH terms

  • Absorbable Implants*
  • Catheters, Indwelling
  • Collagen / administration & dosage
  • Dose Fractionation, Radiation
  • Humans
  • Hyaluronic Acid / administration & dosage
  • Male
  • Polyethylene Glycols / administration & dosage
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / radiotherapy*
  • Radiation Injuries / prevention & control*
  • Radiotherapy Dosage
  • Rectum / radiation effects*


  • Polyethylene Glycols
  • Hyaluronic Acid
  • Collagen