Quantitative assessment of synovitis in Legg-Calvé-Perthes disease using gadolinium-enhanced MRI

J Pediatr Orthop B. 2015 Mar;24(2):89-94. doi: 10.1097/BPB.0000000000000107.

Abstract

A quantitative method to assess hip synovitis in Legg-Calvé-Perthes disease (LCPD) is not currently available. To develop this method, the areas of synovial enhancement on gadolinium-enhanced MRI (Gd-MRI) were measured by two independent observers. The volume of synovial enhancement was significantly increased in the initial and the fragmentation stages of LCPD (Waldenström stages I and II), with a persistence of synovitis into the reossification stage (stage III). The Gd-MRI method had high interobserver and intraobserver agreements and may serve as a useful method to monitor the effect of various treatments on hip synovitis in LCPD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Contrast Media
  • Female
  • Femur Head / pathology*
  • Gadolinium
  • Hip Joint / pathology
  • Humans
  • Legg-Calve-Perthes Disease / diagnosis*
  • Legg-Calve-Perthes Disease / diagnostic imaging
  • Legg-Calve-Perthes Disease / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Observer Variation
  • Prospective Studies
  • Radiography
  • Synovitis / diagnosis*

Substances

  • Contrast Media
  • Gadolinium