A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

doi:10.1038/nbt.3020

. 2014 Nov;32(11):1134-40.

doi: 10.1038/nbt.3020. Epub 2014 Oct 12.

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Daniel C Leslie¹, Anna Waterhouse², Julia B Berthet², Thomas M Valentin³, Alexander L Watters³, Abhishek Jain⁴, Philseok Kim⁵, Benjamin D Hatton⁵, Arthur Nedder⁶, Kathryn Donovan⁶, Elana H Super⁷, Caitlin Howell⁵, Christopher P Johnson⁵, Thy L Vu⁵, Dana E Bolgen⁷, Sami Rifai⁷, Anne R Hansen⁸, Michael Aizenberg⁷, Michael Super⁴, Joanna Aizenberg⁹, Donald E Ingber¹

Affiliations

¹ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
² 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
³ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
⁴ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
⁵ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
⁶ Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
⁷ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
⁸ 1] Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
⁹ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

PMID: 25306244
DOI: 10.1038/nbt.3020

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Daniel C Leslie et al. Nat Biotechnol. 2014 Nov.

. 2014 Nov;32(11):1134-40.

doi: 10.1038/nbt.3020. Epub 2014 Oct 12.

Authors

Affiliations

¹ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
² 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
³ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
⁴ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
⁵ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
⁶ Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
⁷ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
⁸ 1] Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
⁹ 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

PMID: 25306244
DOI: 10.1038/nbt.3020

Abstract

Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.

PubMed Disclaimer

Cited by

Microfluidics at Fiber Tip for Nanoliter Delivery and Sampling.
Barbot A, Wales D, Yeatman E, Yang GZ. Barbot A, et al. Adv Sci (Weinh). 2021 Mar 15;8(10):2004643. doi: 10.1002/advs.202004643. eCollection 2021 May. Adv Sci (Weinh). 2021. PMID: 34026456 Free PMC article.
Hematologic concerns in extracorporeal membrane oxygenation.
Sniderman J, Monagle P, Annich GM, MacLaren G. Sniderman J, et al. Res Pract Thromb Haemost. 2020 May 15;4(4):455-468. doi: 10.1002/rth2.12346. eCollection 2020 May. Res Pract Thromb Haemost. 2020. PMID: 32548547 Free PMC article. Review.
A versatile "3M" methodology to obtain superhydrophobic PDMS-based materials for antifouling applications.
He Z, Yang X, Mu L, Wang N, Lan X. He Z, et al. Front Bioeng Biotechnol. 2022 Aug 29;10:998852. doi: 10.3389/fbioe.2022.998852. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 36105602 Free PMC article. Review.
Nature-Inspired Surface Structures Design for Antimicrobial Applications.
Lee MS, Hussein HR, Chang SW, Chang CY, Lin YY, Chien Y, Yang YP, Kiew LV, Chen CY, Chiou SH, Chang CC. Lee MS, et al. Int J Mol Sci. 2023 Jan 10;24(2):1348. doi: 10.3390/ijms24021348. Int J Mol Sci. 2023. PMID: 36674860 Free PMC article. Review.
Assessing the Reusability of 3D-Printed Photopolymer Microfluidic Chips for Urine Processing.
Lepowsky E, Amin R, Tasoglu S. Lepowsky E, et al. Micromachines (Basel). 2018 Oct 15;9(10):520. doi: 10.3390/mi9100520. Micromachines (Basel). 2018. PMID: 30424453 Free PMC article.

See all "Cited by" articles

References

1. Nephrol Dial Transplant. 2013 Jun;28(6):1589-602 - PubMed
1. Science. 1973 Aug 17;181(4100):680-2 - PubMed
1. Perfusion. 2012 Nov;27(6):530-4 - PubMed
1. Nature. 2011 Sep 21;477(7365):443-7 - PubMed
1. Interact Cardiovasc Thorac Surg. 2012 Nov;15(5):834-9 - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Nephrol Dial Transplant. 2013 Jun;28(6):1589-602 - PubMed

[2] Nephrol Dial Transplant. 2013 Jun;28(6):1589-602 - PubMed

[3] Science. 1973 Aug 17;181(4100):680-2 - PubMed

[4] Science. 1973 Aug 17;181(4100):680-2 - PubMed

[5] Perfusion. 2012 Nov;27(6):530-4 - PubMed

[6] Perfusion. 2012 Nov;27(6):530-4 - PubMed

[7] Nature. 2011 Sep 21;477(7365):443-7 - PubMed

[8] Nature. 2011 Sep 21;477(7365):443-7 - PubMed

[9] Interact Cardiovasc Thorac Surg. 2012 Nov;15(5):834-9 - PubMed

[10] Interact Cardiovasc Thorac Surg. 2012 Nov;15(5):834-9 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Affiliations

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical