Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease

J Dairy Sci. 2014 Dec;97(12):7386-93. doi: 10.3168/jds.2014-8500. Epub 2014 Oct 11.


The aim of this study was to investigate the effects of probiotic yogurt consumption on some metabolic factors in nonalcoholic fatty liver disease (NAFLD) patients. This double-blind, randomized, controlled clinical trial was conducted on 72 patients with NAFLD (33 males and 39 females) aged 23 to 63 yr. Subjects in the intervention group (n=36) consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group (n=36) consumed 300 g/d of conventional yogurt for 8 wk. Fasting blood samples, anthropometric measurements, and dietary records (24h/d for 3 d) were collected at baseline and at the end of the trial. Probiotic yogurt consumption resulted in reductions of 4.67, 5.42, 4.1, and 6.92% in serum levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and low-density lipoprotein cholesterol, respectively, compared with control group. No significant changes were observed in levels of serum glucose, triglycerides, or high-density lipoprotein cholesterol in either group. Probiotic yogurt consumption improved hepatic enzymes, serum total cholesterol, and low-density lipoprotein cholesterol levels in studied subjects and might be useful in management of NAFLD risk factors.

Keywords: metabolic factor; nonalcoholic fatty liver disease; probiotic yogurt.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Bifidobacterium*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Double-Blind Method
  • Female
  • Humans
  • Lactobacillus acidophilus*
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease / therapy*
  • Probiotics / pharmacology*
  • Triglycerides / blood
  • Yogurt / microbiology*
  • Young Adult


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides
  • Cholesterol