The Dpp/TGFβ-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in drosophila embryos

Dev Cell. 2014 Oct 27;31(2):240-7. doi: 10.1016/j.devcel.2014.08.015. Epub 2014 Oct 9.


Jun N-terminal kinase (JNK) often mediates apoptosis in response to cellular stress. However, during normal development, JNK signaling controls a variety of live cell behaviors, such as during dorsal closure in Drosophila embryos. During this process, the latent proapoptotic activity of JNK becomes apparent following Dpp signaling suppression, which leads to JNK-dependent transcriptional activation of the proapoptotic gene reaper. Dpp signaling also protects cells from JNK-dependent apoptosis caused by epithelial disruption. We find that repression of reaper transcription by Dpp is mediated by Schnurri. Moreover, reporter gene analysis shows that a transcriptional regulatory module comprising AP-1 and Schnurri binding sites located upstream of reaper integrate the activities of JNK and Dpp. This arrangement allows JNK to control a migratory behavior without triggering apoptosis. Dpp plays a dual role during dorsal closure. It cooperates with JNK in stimulating cell migration and also prevents JNK from inducing apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • Binding Sites / genetics
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • DNA-Binding Proteins / metabolism*
  • Drosophila Proteins / antagonists & inhibitors
  • Drosophila Proteins / biosynthesis
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / embryology*
  • Embryo, Nonmammalian / pathology
  • Embryonic Development
  • Enzyme Activation / genetics
  • Epithelial Cells / pathology
  • Gene Expression Regulation, Developmental
  • JNK Mitogen-Activated Protein Kinases / metabolism*
  • Promoter Regions, Genetic
  • Transcription Factor AP-1 / metabolism
  • Transcription Factors / metabolism*
  • Transcriptional Activation


  • DNA-Binding Proteins
  • Drosophila Proteins
  • Transcription Factor AP-1
  • Transcription Factors
  • dpp protein, Drosophila
  • rpr protein, Drosophila
  • shn protein, Drosophila
  • JNK Mitogen-Activated Protein Kinases