A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: a randomized placebo-controlled trial

Res Vet Sci. 2014 Dec;97(3):574-81. doi: 10.1016/j.rvsc.2014.09.011. Epub 2014 Sep 28.


An oral herb-based natural health product (NHP) was evaluated in the canine natural osteoarthritis model. At baseline, the peak vertical force (PVF, primary endpoint) and case-specific outcome measure of disability (CSOM) were recorded in privately-owned dogs. Dogs (16/group) were randomized to receive NHP formulations or a negative control. The PVF was measured at week (W) 4 and W8. Daily locomotor activity was recorded using accelerometer. The CSOMs were assessed bi-weekly by the owner. The NHP-treated dogs (n = 13) had higher PVF at W4 (p = 0.020) and W8 (p <0.001) when compared to baseline. The changes at W8 were higher than control dogs (n = 14, p <0.027) and consistent with Cohen's d effect size of 0.7 (95% confidence interval: 0.0-1.5). The NHP-treated dogs had higher locomotor activity at W8 (p = 0.025) when compared to baseline. No significant change was observed for the CSOM. The NHP improved the clinical signs of osteoarthritis in this model.

Keywords: Canine model; Force platform; Locomotor activity; Naturally-occurring osteoarthritis; Phytochemical compounds.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Ananas / chemistry
  • Animals
  • Boswellia / chemistry
  • Curcuma / chemistry
  • Dog Diseases / drug therapy*
  • Dog Diseases / pathology*
  • Dogs
  • Harpagophytum / chemistry
  • Locomotion / drug effects
  • Osteoarthritis / drug therapy
  • Osteoarthritis / pathology
  • Osteoarthritis / veterinary*
  • Phytotherapy / methods
  • Phytotherapy / veterinary*
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*
  • Ribes / chemistry
  • Salix / chemistry
  • Tanacetum parthenium / chemistry
  • Time Factors
  • Treatment Outcome


  • Plant Extracts