The regulation role of interferon regulatory factor-1 gene and clinical relevance

Hum Immunol. 2014 Nov;75(11):1110-4. doi: 10.1016/j.humimm.2014.09.015. Epub 2014 Oct 13.


IRF-1, a kind of transcription factors, is expressed constitutively in all cells types except early embryonal cells. By virtue of its interaction with specific DNA sequence, IRF-1 regulates the transcription of a set of target genes which play essential roles in various physiological and pathological processes, including viral infection, tumor immune surveillance, pro-inflammatory injury, development of immunity system. What's more, IRF-1 also interacts with other transcription factors to regulate the specific genes transcription in the nucleus. In immunity system, IRF-1 is suggested to provide a link between innate and adoptive immune system. Although IRF-1 has been demonstrated with essential role in human immunity, the comprehensive understanding of the role of IRF-1 has been restrained because of extensive target genes, Here, we review the clinical relevance of IRF-1 and underlying mechanism based on the latest researches.

Keywords: IRF-1; Immune system; Infection; Injury; Interaction; Oncogenesis.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Autoimmunity
  • Gene Expression Regulation / immunology*
  • Humans
  • Immunity, Innate
  • Immunologic Surveillance / genetics
  • Inflammation / genetics
  • Inflammation / immunology
  • Inflammation / pathology
  • Interferon Regulatory Factor-1 / genetics*
  • Interferon Regulatory Factor-1 / immunology
  • Neoplasms / genetics*
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Reperfusion Injury / genetics*
  • Reperfusion Injury / immunology
  • Reperfusion Injury / pathology
  • Signal Transduction
  • Transcription, Genetic
  • Virus Diseases / genetics*
  • Virus Diseases / immunology
  • Virus Diseases / pathology
  • Virus Diseases / virology


  • IRF1 protein, human
  • Interferon Regulatory Factor-1