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Failure or Success of Search Strategies to Identify Adverse Effects of Medical Devices: A Feasibility Study Using a Systematic Review


Failure or Success of Search Strategies to Identify Adverse Effects of Medical Devices: A Feasibility Study Using a Systematic Review

Su Golder et al. Syst Rev.


Background: Research has indicated that adverse effects terms are increasingly prevalent in the title, abstract or indexing terms of articles that contain adverse drug effects data in MEDLINE and Embase. However, it is unknown whether adverse effects terms are present in the database records of articles that contain adverse effects data of medical devices, and thus, to what extent the development of an adverse effects search filter for medical devices may be feasible.

Methods: A case study systematic review of a medical device was selected. The included studies from a systematic review of the safety of recombinant human bone morphogenetic protein-2 (rhBMP-2) for spinal fusion were used in the analysis. For each included study, the corresponding database record on MEDLINE and Embase was assessed to measure the presence or absence of adverse effects terms in the title, abstract or indexing. The performance of each potential adverse effects search term was also measured and compared.

Results: There were 82 publications (49 studies) included in the systematic review with 51 of these indexed on MEDLINE and 55 on Embase. Ninety-four percent (48/51) of the records on MEDLINE and 95% (52/55) of the records on Embase contained at least one adverse effects related search term. The wide variety of adverse effects terms included in the title, abstract or indexing of bibliographic records, and the lack of any individual high-performing search terms suggests that a combination of terms in different fields is required to identify adverse effects of medical devices. In addition, the most successful search terms differed from the most successful terms for identifying adverse drug effects.

Conclusions: The search filters currently available for adverse drug effects are not necessarily useful for searching adverse effects data of medical devices. The presence of adverse effects terms in the bibliographic records of articles on medical devices, however, indicates that combinations of adverse effects search terms may be useful in search strategies in MEDLINE and Embase. The results, therefore, suggest that not only a search filter for the adverse effects of medical devices is feasible, but also that it should be a research priority.

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    1. Chou RAN, Atkinsc D, Ismailad AS, Santaguidad P, Smith DH, Whitlock E, Wilt TJ, Moher D. AHRQ Series Paper 4: assessing harms when comparing medical interventions: AHRQ and the effective health-care program. J Clin Epidemiol. 2010;63:502–512. doi: 10.1016/j.jclinepi.2008.06.007. - DOI - PubMed
    1. Golder SLY. Search strategies to identify information on adverse effects: a systematic review. J Med Libr Assoc. 2009;97(2):84–92. doi: 10.3163/1536-5050.97.2.004. - DOI - PMC - PubMed
    1. Golder S, Loke YK. The performance of adverse effects search filters in MEDLINE and EMBASE. Health Inf Libr J. 2012;29(2):141–151. doi: 10.1111/j.1471-1842.2012.00980.x. - DOI - PubMed
    1. Golder S, Loke YK. Failure or success of electronic search strategies to identify adverse effects data. J Med Libr Assoc. 2012;100(2):130–134. doi: 10.3163/1536-5050.100.2.012. - DOI - PMC - PubMed
    1. Farrah KMU, Cimon MK. Playing it safe: validating search filters for adverse events. Poster presented at: 2013 Annual Meeting and Exhibition of the Medical Library Association Add to My Files (MLA ‘13), the 11th International Congress on Medical Librarianship (ICML), the 7th International Conference of Animal Health Information Specialists (ICAHIS), and the 6th International Clinical Librarian Conference (ICLC) One Health: Information in an Interdependent World; 2013 May 3–8. Boston, MA. Available from:

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