Reprogramming the tumor stroma: a new paradigm

Cancer Cell. 2014 Oct 13;26(4):451-2. doi: 10.1016/j.ccell.2014.09.016.


A recent article in Cell shows that vitamin D receptor activation reprograms reactive stroma in the tumor microenvironment to a less inflammatory, quiescent state and is associated with increased drug retention, tumor response, and survival in pancreatic cancer models. Stroma reprogramming, as opposed to ablation, may emerge as a new treatment paradigm.

MeSH terms

  • Cellular Reprogramming*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Receptors, Calcitriol / metabolism
  • Stromal Cells / metabolism
  • Stromal Cells / pathology*


  • Receptors, Calcitriol