Efficacy of a standardized isopropanolic black cohosh (Actaea racemosa) extract in treatment of uterine fibroids in comparison with tibolone among patients with menopausal symptoms

Holist Nurs Pract. Nov-Dec 2014;28(6):386-91. doi: 10.1097/HNP.0000000000000055.


Both therapies demonstrated efficacy in relieving menopausal symptoms; however, isopropanolic black cohosh (Remifemin) seems to be a more appropriate choice in alleviating menopausal symptoms in women with uterine fibroid. Isopropanolic black cohosh seems to be a valid treatment option in patients with uterine fibroids, as it provides adequate relief from menopausal symptoms and avoids increase in uterine fibroid size, which is usually a cause of concern for the patient.

Publication types

  • Review

MeSH terms

  • Adult
  • Cimicifuga / chemistry*
  • Female
  • Hormone Replacement Therapy
  • Hot Flashes / drug therapy*
  • Humans
  • Leiomyoma / drug therapy*
  • Menopause*
  • Middle Aged
  • Norpregnenes / therapeutic use*
  • Phytotherapy / methods
  • Plant Extracts / therapeutic use*


  • Norpregnenes
  • Plant Extracts
  • tibolone