Surgical and systemic management of endometrial cancer: an international survey

Arch Gynecol Obstet. 2015 Apr;291(4):897-905. doi: 10.1007/s00404-014-3510-3. Epub 2014 Oct 15.


Purpose: To ascertain the spectrum of clinical management of endometrial carcinoma (EC) the largest international survey was conducted to evaluate and identify differences worldwide.

Methods: After validation of a 15-item questionnaire regarding surgical and adjuvant treatment of EC in Germany, an English-adapted questionnaire was put online and posted to all the major gynecological cancer Societies worldwide for further distribution commencing in 2010 and continued for 26 months.

Results: A total of 618 Institutions around the world participated: Central Europe (CE), Southern Europe (SE), Northern Europe (NE), Asia and USA/Canada/UK. Both a therapeutic and staging value was attributed to systematic pelvic and paraaortic lymph node dissection (LND) in CE (74.6%) and in Asia (67.2%), as opposed to USA/UK where LND was mainly for staging purposes (53.5%; p < 0.001). LND was performed up to the renal veins in CE in 86.8%, in Asia in 80.8%, in USA/UK in 51.2% and in SE in 45.1% (p < 0.001) of cases. In advanced disease, centers from Asia were treated most with adjuvant chemotherapy alone (93.6%), as opposed to centers in SE, CE and UK/USA that employed combination chemo-radiotherapy in 90.9% (p < 0.001) of cases. Paclitaxel/carboplatin was mostly used followed by doxorubicin/cisplatin (75 vs. 23.3%; p < 0.001). In total, 94% of all participants supported the concept of treating EC patients within appropriate clinical trials.

Conclusions: There is broad range in both the surgical and adjuvant treatment of EC across different countries. Large-scale multicenter prospective trials are warranted to establish consistent, evidence-based guidelines to optimize treatment worldwide.

MeSH terms

  • Adjuvants, Immunologic
  • Aged
  • Chemotherapy, Adjuvant
  • Diagnostic Techniques, Obstetrical and Gynecological / statistics & numerical data
  • Drug Therapy, Combination
  • Endometrial Neoplasms / diagnosis
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / therapy*
  • Ethnicity
  • Female
  • Guideline Adherence* / statistics & numerical data
  • Gynecologic Surgical Procedures / statistics & numerical data
  • Health Surveys
  • Humans
  • Lymph Node Excision
  • Practice Patterns, Physicians'*
  • Professional Practice / standards
  • Professional Practice / statistics & numerical data*
  • Prospective Studies
  • Radiotherapy, Adjuvant
  • Reproducibility of Results
  • Surveys and Questionnaires*


  • Adjuvants, Immunologic