miR-545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG-I

FEBS Lett. 2014 Nov 28;588(23):4375-81. doi: 10.1016/j.febslet.2014.10.004. Epub 2014 Oct 12.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer-related causes of death. Deregulation or dysfunction of miRNAs contribute to cancer development. In this study, we found that low miR-545 level and high RIG-I protein in PDAC tissues were both correlated with low survival rate. MiR-545 up-regulation inhibited PDAC cell lines growth and vice versa. 3'UTR of RIG-I was targeted by miR-545. Thus we concluded that low miR-545 levels in PDAC promote tumor cells growth, and this is associated with reduced survival in PDAC patients. MiR-545 exerts its effects by directly targeting RIG-1.

Keywords: Cancer growth; Pancreatic ductal adenocarcinoma; Patients survival; RIG-I; miR-545.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions / genetics
  • Base Sequence
  • Carcinoma, Pancreatic Ductal / genetics*
  • Carcinoma, Pancreatic Ductal / metabolism
  • Carcinoma, Pancreatic Ductal / pathology*
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / genetics*
  • DEAD-box RNA Helicases / metabolism
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology*
  • Receptors, Immunologic
  • Survival Analysis

Substances

  • 3' Untranslated Regions
  • MIR545 microRNA, human
  • MicroRNAs
  • Receptors, Immunologic
  • RIGI protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases