Aging reduces experience-induced sensorimotor plasticity. A magnetoencephalographic study

Neuroimage. 2015 Jan 1;104:59-68. doi: 10.1016/j.neuroimage.2014.10.010. Epub 2014 Oct 12.

Abstract

Modulation of the mu-alpha and mu-beta spontaneous rhythms reflects plastic neural changes within the primary sensorimotor cortex (SM1). Using magnetoencephalography (MEG), we investigated how aging modifies experience-induced plasticity after learning a motor sequence, looking at post- vs. pre-learning changes in the modulation of mu rhythms during the execution of simple hand movements. Fifteen young (18-30 years) and fourteen older (65-75 years) right-handed healthy participants performed auditory-cued key presses using all four left fingers simultaneously (Simple Movement task - SMT) during two separate sessions. Following both SMT sessions, they repeatedly practiced a 5-elements sequential finger-tapping task (FTT). Mu power calculated during SMT was averaged across 18 gradiometers covering the right sensorimotor region and compared before vs. after sequence learning in the alpha (9/10/11Hz) and the beta (18/20/22Hz) bands separately. Source power maps in the mu-alpha and mu-beta bands were localized using Dynamic Statistical Parametric Mapping (dSPM). The FTT sequence was performed faster at retest than at the end of the learning session, indicating an offline boost in performance. Analyses conducted on SMT sessions revealed enhanced rebound after learning in the right SM1, 3000-3500ms after the initiation of movement, in young as compared to older participants. Source reconstruction indicated that mu-beta is located in the precentral gyrus (motor processes) and mu-alpha is located in the postcentral gyrus (somatosensory processes) in both groups. The enhanced post-movement rebound in young subjects potentially reflects post-training plastic changes in SM1. Age-related decreases in post-training modulatory effects suggest reduced experience-dependent plasticity in the aging brain.

Keywords: Aging; Magnetoencephalography; Motor learning; Mu rhythm; Power change; Rebound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Aged
  • Aging / physiology*
  • Alpha Rhythm
  • Beta Rhythm
  • Brain Mapping
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetoencephalography
  • Male
  • Motor Skills
  • Neuronal Plasticity / physiology*
  • Psychomotor Performance / physiology
  • Reaction Time / physiology
  • Surveys and Questionnaires
  • Young Adult