Significance of MTA1 in the Molecular Characterization of Osteosarcoma

Cancer Metastasis Rev. 2014 Dec;33(4):981-91. doi: 10.1007/s10555-014-9523-3.

Abstract

Osteosarcoma is the most common malignant bone tumor in children and characterized by aggressive biologic behavior of metastatic propensity to the lung. Change of treatment paradigm brings survival benefit; however, 5-year survival rate is still low in patients having metastastatic foci at diagnosis for a few decades. Metastasis-associated protein (MTA) family is a group of ubiquitously expressed coregulators, which influences on tumor invasiveness or metastasis. MTA1 has been investigated in various cancers including osteosarcoma, and its overexpression is associated with high-risk features of cancers. In this review, we described various molecular studies of osteosarcoma, especially associated with MTA1.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / genetics*
  • Bone Neoplasms / pathology
  • Chromatin Assembly and Disassembly / genetics
  • Histone Deacetylases / genetics*
  • Humans
  • MicroRNAs / genetics
  • Neoplasm Invasiveness / genetics
  • Osteosarcoma / genetics*
  • Osteosarcoma / pathology
  • Repressor Proteins / genetics*

Substances

  • MicroRNAs
  • Mta1 protein, human
  • Repressor Proteins
  • Histone Deacetylases