Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice

Exp Dermatol. 2015 Jan;24(1):55-7. doi: 10.1111/exd.12568. Epub 2014 Nov 20.


Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression increases in response to epidermal barrier challenges. In this study, we report the generation of Calm4 knockout mice and provide evidence that Calm4 is dispensable for epidermal barrier formation, maintenance and repair.

Keywords: calcium-binding protein; epidermis; skin barrier; wound repair.

Publication types

  • Letter
  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Calcium-Binding Proteins / chemistry
  • Calmodulin / genetics
  • Calmodulin / physiology*
  • Calpain / genetics
  • Calpain / physiology*
  • Cell Movement
  • Epidermis / metabolism*
  • Keratinocytes / cytology
  • Lac Operon
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phenotype
  • Signal Transduction
  • Skin / metabolism
  • Wound Healing


  • Calcium-Binding Proteins
  • Calmodulin
  • Calm4 protein, mouse
  • Calpain