Mammalian lipoxygenases and their biological relevance

Biochim Biophys Acta. 2015 Apr;1851(4):308-30. doi: 10.1016/j.bbalip.2014.10.002. Epub 2014 Oct 12.


Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated not only in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other fatty acid dioxygenases LOXs oxidize polyunsaturated fatty acids to their corresponding hydroperoxy derivatives, which are further transformed to bioactive lipid mediators (eicosanoids and related substances). On the other hand, lipoxygenases are key players in the regulation of the cellular redox homeostasis, which is an important element in gene expression regulation. Although the first mammalian lipoxygenases were discovered 40 years ago and although the enzymes have been well characterized with respect to their structural and functional properties the biological roles of the different lipoxygenase isoforms are not completely understood. This review is aimed at summarizing the current knowledge on the physiological roles of different mammalian LOX-isoforms and their patho-physiological function in inflammatory, metabolic, hyperproliferative, neurodegenerative and infectious disorders. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".

Keywords: Atherosclerosis; Cancer; Eicosanoid; Infection; Inflammation; Stroke.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / enzymology
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / enzymology
  • Fatty Acids, Unsaturated / metabolism*
  • Homeostasis
  • Humans
  • Inflammation / metabolism
  • Isoenzymes
  • Lipoxygenase Inhibitors / therapeutic use
  • Lipoxygenases / chemistry
  • Lipoxygenases / classification
  • Lipoxygenases / genetics
  • Lipoxygenases / metabolism*
  • Metabolic Diseases / drug therapy
  • Metabolic Diseases / enzymology
  • Models, Molecular
  • Oxidation-Reduction
  • Protein Conformation
  • Signal Transduction


  • Fatty Acids, Unsaturated
  • Isoenzymes
  • Lipoxygenase Inhibitors
  • Lipoxygenases