Bridging lipid metabolism and innate host defense

Claudia dos Santos; John C Marshall

doi:10.1126/scitranslmed.3010501

Bridging lipid metabolism and innate host defense

Sci Transl Med. 2014 Oct 15;6(258):258fs41. doi: 10.1126/scitranslmed.3010501.

Authors

Claudia dos Santos¹, John C Marshall²

Affiliations

¹ Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
² Department of Critical Care Medicine and the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada. marshallj@smh.ca.

PMID: 25320231
DOI: 10.1126/scitranslmed.3010501

Abstract

Host- and pathogen-derived lipids share clearance mechanisms that pinpoint PCSK9 as a plausible target for the treatment of some patients with sepsis (Walley et al., this issue).

Publication types

Comment

MeSH terms

Animals
Humans
Immunity, Innate*
Male
Proprotein Convertases / metabolism*
Serine Endopeptidases / metabolism*
Shock, Septic / immunology*
Shock, Septic / metabolism*

Substances

Proprotein Convertases
Serine Endopeptidases