Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors

J Virol. 2015 Jan;89(1):857-62. doi: 10.1128/JVI.02328-14. Epub 2014 Oct 15.


Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Viral, Tumor / metabolism*
  • Child
  • Child, Preschool
  • DNA, Viral / chemistry
  • DNA, Viral / genetics
  • Female
  • Host-Pathogen Interactions*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polyomavirus / physiology*
  • Polyomavirus Infections / epidemiology*
  • Polyomavirus Infections / virology
  • Protein Binding
  • Sequence Analysis, DNA
  • Seroepidemiologic Studies
  • Tumor Suppressor Proteins / metabolism*
  • Young Adult


  • Antigens, Viral, Tumor
  • DNA, Viral
  • Tumor Suppressor Proteins

Associated data

  • GENBANK/KC690147