A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor

FEBS Lett. 1989 Dec 4;258(2):301-4. doi: 10.1016/0014-5793(89)81679-5.


A cDNA clone, which represents a species of mRNA that is expressed in growth-stimulated BALB/c-3T3 cells but not in resting cells, was found to encode a protein remarkably similar in sequence to the members of the immunoglobulin superfamily, especially to the extracellular portion of the mouse interleukin 1 receptor. The immunoglobulin superfamily is believed to be involved in cell adhesion and cell-to-cell interaction. The evidence that a member of this family is induced in the course of the initiation of cell proliferation is intriguing.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Cycle
  • Cell Division
  • Cells, Cultured
  • Cloning, Molecular
  • DNA / genetics*
  • Genes, Immunoglobulin
  • Immunoglobulins / genetics*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Multigene Family
  • Proteins / genetics*
  • RNA, Messenger / genetics
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin-1
  • Sequence Homology, Nucleic Acid


  • Immunoglobulins
  • Proteins
  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Interleukin-1
  • DNA

Associated data

  • GENBANK/Y07519