Zebrafish as a model to study live mucus physiology

Sci Rep. 2014 Oct 17;4:6653. doi: 10.1038/srep06653.

Abstract

Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gastrointestinal Tract / physiology
  • Models, Biological
  • Mucins / genetics*
  • Mucins / metabolism
  • Mucus / physiology*
  • Respiratory System / physiopathology
  • Urogenital System / physiology
  • Zebrafish / genetics*
  • Zebrafish / physiology

Substances

  • Mucins