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. 2015 Apr;18(4):409-14.
doi: 10.1089/jmf.2014.3241. Epub 2014 Oct 17.

Nobiletin Protects Dopaminergic Neurons in the 1-methyl-4-phenylpyridinium-treated Rat Model of Parkinson's Disease

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Nobiletin Protects Dopaminergic Neurons in the 1-methyl-4-phenylpyridinium-treated Rat Model of Parkinson's Disease

Kyoung Hoon Jeong et al. J Med Food. .

Abstract

This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson's disease (PD). 1-Methyl-4-phenylpyridinium (MPP(+)) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP(+)-treated rats. In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.

Keywords: GDNF; MPP+; dopaminergic neuron; microglia; neuroprotection; nobiletin.

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