Liraglutide-induced acute pancreatitis

J Assoc Physicians India. 2014 Jan;62(1):64-6.

Abstract

An obese lady of 51 year with Type 2 Diabetes Mellitus for 13 years was prescribed Liraglutide, a glucagon like peptide (GLP-1) analogue (Victoza) for glycaemic control and reduction of weight. She was on gliclazide and Insulin prior to initiation of Liraglutide. Eight weeks after initiation of GLP -1 analogue, she developed severe abdominal pain, nausea and vomiting. She was admitted to a private hospital and evaluated. Biochemical tests and CT scan revealed presence of pancreatitis and she was treated for acute pancreatitis. Liraglutide was withdrawn and symptoms subsided. Subsequent follow-up showed that pancreatic enzyme levels were normal.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Diabetes Mellitus, Type 2 / drug therapy
  • Female
  • Glucagon-Like Peptide 1 / administration & dosage
  • Glucagon-Like Peptide 1 / adverse effects
  • Glucagon-Like Peptide 1 / analogs & derivatives*
  • Humans
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / adverse effects*
  • Liraglutide
  • Middle Aged
  • Pancreatitis / chemically induced*

Substances

  • Hypoglycemic Agents
  • Liraglutide
  • Glucagon-Like Peptide 1