This thematic issue of Cell & Bioscience highlights review articles by Sophia Y. Tsai and Ming-Jer Tsai's research team on roles of COUP-TFII in tumor progression and metastasis and by Hui-Kuan Lin and his colleagues on posttranslational regulation of Akt in human cancer. Drs. Sophia Tsai and Ming-Jer Tsai were the 2013 Society of Chinese Bioscientists in America (SCBA) Lifetime Achievement Award winners. Dr. Hui-Kuan Lin was the 2013 SCBA Outstanding Young Investigator Award winner.