Unique reactions of scrotal skin to topical agents

Cutis. 1989 Dec;44(6):445-7.


Topical agents that do not produce irritant reaction elsewhere on the skin readily produce irritant dermatitis and even ulceration when applied to scrotal skin. As Shelley and Shelley state: "The scrotum must be recognized as a skin area with remarkable permeability. It provides a unique percutaneous doorway for the entrance of drugs into the circulation and is thus uniquely susceptible to toxic and irritant agents."

Publication types

  • Case Reports
  • Review

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Aluminum Hydroxide / adverse effects
  • Astringents / adverse effects
  • Drug Eruptions / etiology*
  • Hair Removal / adverse effects
  • Humans
  • Irritants / adverse effects*
  • Male
  • Podophyllin / adverse effects
  • Scrotum / drug effects*
  • Thioglycolates / adverse effects


  • Astringents
  • Irritants
  • Thioglycolates
  • aluminum oxychloride
  • Aluminum Hydroxide
  • 2-mercaptoacetate
  • Podophyllin