Antimicrobial γ-AApeptides (WO2013112548): a patent evaluation

Expert Opin Ther Pat. 2015 Jan;25(1):111-8. doi: 10.1517/13543776.2014.973855. Epub 2014 Oct 21.

Abstract

The patent application WO2013112548 claims a new class of peptidomimetics - γ-AApeptides with potent and broad-spectrum antimicrobial activity. These γ-AApeptides are active against both Gram-positive and Gram-negative bacteria, including medicinally relevant drug-resistant pathogens. They are believed to exert bactericidal function by mimicking the membrane disruption mechanism of host-defense peptides. As such, they may provide an alternative approach for antimicrobial development combating antibiotic resistance.

Keywords: Gram-positive and Gram-negative; antimicrobial; membrane disruption; peptidomimetics; γ-AApeptides.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Antimicrobial Cationic Peptides / chemistry
  • Antimicrobial Cationic Peptides / pharmacology*
  • Antimicrobial Cationic Peptides / therapeutic use
  • Bacteria / drug effects
  • Bacteria / growth & development
  • Drug Design
  • Drug Industry / legislation & jurisprudence*
  • Drug Resistance, Bacterial
  • Humans
  • Molecular Structure
  • Patents as Topic*
  • Peptidomimetics / chemistry
  • Peptidomimetics / pharmacology*
  • Peptidomimetics / therapeutic use
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • Peptidomimetics