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Case Reports
. 2014 Oct 1;3:578.
doi: 10.1186/2193-1801-3-578. eCollection 2014.

Determination of Superoxide Dismutase Mimetic Activity in Common Culinary Herbs

Free PMC article
Case Reports

Determination of Superoxide Dismutase Mimetic Activity in Common Culinary Herbs

Magali Chohan et al. Springerplus. .
Free PMC article


Background: Under conditions of oxidative stress, the removal of superoxide, a free radical associated with chronic inflammation, is catalysed by superoxide dismutase (SOD). Thus in addition to acting as an antioxidant, SOD may also be utilized as an anti-inflammatory agent. Some plant derived foods have been shown to have SOD mimetic (SODm) activity however it is not known if this activity is possessed by culinary herbs which have previously been shown to possess both antioxidant and anti-inflammatory properties. The aim of the study was to ascertain if the culinary herbs rosemary, sage and thyme possess SODm activity, and to investigate the influence of cooking and digestion on this activity. Transition metal ion content was also determined to establish if it could likely contribute to any SODm activity detected.

Findings: All extracts of uncooked (U), cooked (C) and cooked and digested (C&D) herbs were shown to possess SODm activity, which was significantly correlated with previously determined antioxidant and anti-inflammatory activities of these herbs. SODm activity was significantly increased following (C) and (C&D) for rosemary and sage only. The impact of (C) and (C&D) on the SODm for thyme may have been influenced by its transition metal ion content.

Conclusions: SODm activity may contribute to the herbs' antioxidant and anti-inflammatory activities however the source and significance of this activity need to be established.

Keywords: Anti-inflammatory; Antioxidant; Culinary herbs; Superoxide dismutase mimetic activity.

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    1. Candy CSC, Waisundara V, Hoon LY. Evaluation and Characterization of Antioxidant Activity of Selected Herbs and Spices. J of Nat Rem. 2013;13:95–103.
    1. Carillon J, Knabe L, Montalban A, Stévant MM, Keophiphath M, Lacan D, Cristol J-P, Rouanet J-M. Curative diet supplementation with a melon superoxide dismutase reduces adipose tissue in obese hamsters by improving insulin sensitivity. Mol Nutr Food Res. 2013;58:842–850. doi: 10.1002/mnfr.201300466. - DOI - PubMed
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