Quality of life after acute pancreatitis: a systematic review and meta-analysis

Pancreas. 2014 Nov;43(8):1194-200. doi: 10.1097/MPA.0000000000000189.


Patient-centered outcomes, including quality of life (QoL), after acute pancreatitis (AP) remain largely unknown. Our aim was to systematically review the best available evidence on QoL after AP. English-language articles on the effect of AP on QoL were identified in MEDLINE, EMBASE, and Scopus. Results were statistically aggregated to obtain a pooled mean difference (MD) and corresponding 95% confidence interval (CI) for individual QoL domains and component summaries, where appropriate. A total of 16 prospective observational studies encompassing 687 AP patients were included. Four studies comprising 267 AP patients, as measured by SF-36 and SF-12 questionnaires, were suitable for meta-analysis. The general health and vitality domains were significantly worse in the patients compared with healthy controls (MD, -10.90; 95% CI, -15.63 to -6.17; P < 0.00001 and MD, -4.64; 95% CI, -7.32 to -1.95; P = 0.0007, respectively). The remaining individual domains and physical and mental component summary scores did not differ between patients and controls. The QoL seems to be significantly impaired in patients after AP with a need to standardize reporting on QoL. Future studies should investigate the effect of different interventions on patients' QoL.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Activities of Daily Living
  • Convalescence
  • Emotions
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Observational Studies as Topic
  • Pain / epidemiology
  • Pain / etiology
  • Pancreatitis / psychology*
  • Pancreatitis / therapy
  • Prospective Studies
  • Quality of Life*
  • Research Design
  • Social Behavior
  • Treatment Outcome