Sonographic findings in patients with Crimean-Congo hemorrhagic fever

J Ultrasound Med. 2014 Nov;33(11):1999-2003. doi: 10.7863/ultra.33.11.1999.


Objectives: Crimean-Congo hemorrhagic fever (CCHF) has been endemic in Turkey since 2002. Some radiologic findings are considered common by clinicians and radiologists. In this regard, we aimed to assess the sonographic findings in patents with CCHF in a pilot study to obtain basic knowledge for planning further controlled studies.

Methods: An observational descriptive study was planned. Patients with a CCHF diagnosis monitored by the infectious diseases department of a tertiary care hospital were included. Sonographic examinations were conducted by 2 radiologists for each patient, and the findings were recorded.

Results: Twenty-five patients with CCHF were included. Hepatomegaly (40%), splenomegaly (28%), paraceliac lymphadenopathy (48%), gallbladder wall thickening (36%), increased echogenicity in the renal parenchyma (40%), and fluid/effusion in the perihepatic, perisplenic, pleural, and hepatorenal recesses of the subhepatic space (Morison pouch) as well as between the intestinal loops (52%) were the primary findings. A decrease in the gallbladder wall thickening and limited resorption of intraperitoneal and pleural effusion were noted during follow-up.

Conclusions: Hepatosplenomegaly, paraceliac lymphadenopathy, and gallbladder wall thickening as well as intraperitoneal and pleural effusion were the primary findings in CCHF, and they became prominent on the third day of the disease in some patients. The relationship between sonographic findings and disease severity will be investigated in an upcoming study.

Keywords: Crimean-Congo hemorrhagic fever; gastrointestinal ultrasound; imaging; sonography; viral hemorrhagic fever.

Publication types

  • Observational Study

MeSH terms

  • Ascitic Fluid / diagnostic imaging
  • Female
  • Gallbladder Diseases / diagnostic imaging*
  • Hemorrhagic Fever, Crimean / diagnostic imaging*
  • Hepatomegaly / diagnostic imaging*
  • Humans
  • Kidney Diseases / diagnostic imaging*
  • Lymphatic Diseases / diagnostic imaging*
  • Male
  • Pleural Effusion / diagnostic imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Splenomegaly / diagnostic imaging*
  • Ultrasonography / methods*