Protein O-GlcNAcylation and cardiovascular (patho)physiology

J Biol Chem. 2014 Dec 12;289(50):34449-56. doi: 10.1074/jbc.R114.585984. Epub 2014 Oct 21.


Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.

Keywords: Calcium; Cardiac Hypertrophy; Cardiovascular; Epigenetics; O-Linked N-Acetylglucosamine (O-GlcNAc).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylglucosamine / metabolism*
  • Animals
  • Calcium Signaling
  • Cardiovascular System / cytology
  • Cardiovascular System / metabolism
  • Cardiovascular System / pathology
  • Cardiovascular System / physiopathology*
  • Epigenesis, Genetic
  • Glycosylation
  • Humans
  • Proteins / genetics
  • Proteins / metabolism*


  • Proteins
  • Acetylglucosamine