NK/T cell lymphoma involving mediastinum: report of a case and review of literature

Int J Clin Exp Pathol. 2014 Aug 15;7(9):6399-402. eCollection 2014.

Abstract

Extranodal natural killer (NK)/T-cell lymphoma is a very aggressive malignant neoplasia with a poor prognosis. Herein we reported a case of NK/T cell lymphoma involving mediastinum. It was a 28-year-old Chinese male patient. The tumor cells were medium-sized, had irregularly folded nuclei, and inconspicuous or small nucleoli with coagulative necrosis. The tumor cells were positive for CD3ε, TIA-1, but negative for CD56. In situ hybridization revealed that tumor cells also expressed Epstein-Barr virus encoded RNA. To our knowledge, this is the first case of NK/T cell lymphoma involving mediastinum.

Keywords: Epstein-Barr virus; NK/T cell lymphoma; mediastinum.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Epididymis / immunology
  • Epididymis / pathology*
  • Epididymis / virology
  • Fatal Outcome
  • Genital Neoplasms, Male / immunology
  • Genital Neoplasms, Male / pathology*
  • Genital Neoplasms, Male / virology
  • Herpesvirus 4, Human / genetics
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphoma, Extranodal NK-T-Cell / immunology
  • Lymphoma, Extranodal NK-T-Cell / pathology*
  • Lymphoma, Extranodal NK-T-Cell / virology
  • Male
  • Mediastinal Neoplasms / immunology
  • Mediastinal Neoplasms / pathology*
  • Mediastinal Neoplasms / virology
  • RNA, Viral / genetics
  • Time Factors
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • RNA, Viral