A facile and general approach to 3-((trifluoromethyl)thio)-4H-chromen-4-one

Haoyue Xiang; Chunhao Yang

doi:10.1021/ol502751k

A facile and general approach to 3-((trifluoromethyl)thio)-4H-chromen-4-one

Org Lett. 2014 Nov 7;16(21):5686-9. doi: 10.1021/ol502751k. Epub 2014 Oct 22.

Authors

Haoyue Xiang¹, Chunhao Yang

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai, 201203, China.

PMID: 25338291
DOI: 10.1021/ol502751k

Abstract

A facile and efficient synthetic strategy to 3-((trifluoromethyl)thio)-4H-chromen-4-one was developed. AgSCF3 and trichloroisocyanuric acid were employed here to generate active electrophilic trifluoromethylthio species in situ. This reaction could proceed under mild conditions in a short reaction time and be insensitive to air and moisture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Chromones / chemical synthesis*
Chromones / chemistry
Hydrocarbons, Halogenated / chemistry*
Molecular Structure
Silver / chemistry*
Triazines / chemistry*

Substances

3-((trifluoromethyl)thio)-4H-chromen-4-one
Chromones
Hydrocarbons, Halogenated
Triazines
trichloroisocyanuric acid
Silver