A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study

Br J Dermatol. 1989 Oct;121(4):497-502. doi: 10.1111/j.1365-2133.1989.tb15518.x.


A double-blind, randomized multi-centre study was performed to evaluate the efficacy of a 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm). One-hundred and twenty-two patients suffering from acne vulgaris were treated with either Zineryt lotion or 2% erythromycin lotion. Acne grading and lesion counts for comedones, papules, pustules, nodules and macules were performed at each visit at 0, 1, 2, 4, 8 and 12 weeks. Treatment with Zineryt lotion was found to be more effective than with 2% erythromycin as regards the reduction in number of the acne lesions and the severity grade of the acne.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Acetates / therapeutic use*
  • Acetic Acid
  • Acne Vulgaris / drug therapy*
  • Adolescent
  • Adult
  • Double-Blind Method
  • Drug Combinations
  • Erythromycin / therapeutic use*
  • Humans
  • Multicenter Studies as Topic
  • Randomized Controlled Trials as Topic


  • Acetates
  • Drug Combinations
  • Erythromycin
  • Acetic Acid