The molecular machinery of neurotransmitter release (Nobel lecture)

Angew Chem Int Ed Engl. 2014 Nov 17;53(47):12696-717. doi: 10.1002/anie.201406359. Epub 2014 Oct 22.

Abstract

The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca(2+) -channels allows rapid translation of the entering Ca(2+) signal into a fusion event.

Keywords: hormone secretion; intracellular signaling; membrane fusion; synaptic plasticity; vesicular transport.

Publication types

  • Lecture
  • Review

MeSH terms

  • Calcium / metabolism
  • Humans
  • Membrane Fusion
  • Neuronal Plasticity
  • Neurotransmitter Agents / metabolism*
  • Nobel Prize
  • SNARE Proteins / metabolism
  • Synaptotagmins / metabolism

Substances

  • Neurotransmitter Agents
  • SNARE Proteins
  • Synaptotagmins
  • Calcium