CD4+ and CD8+ T Cell Activation Are Associated With HIV DNA in Resting CD4+ T Cells

PLoS One. 2014 Oct 23;9(10):e110731. doi: 10.1371/journal.pone.0110731. eCollection 2014.

Abstract

The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • ADP-ribosyl Cyclase 1 / metabolism
  • Adult
  • Biomarkers / metabolism
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • DNA, Viral / immunology*
  • Disease Reservoirs / virology
  • Female
  • HIV Infections / immunology*
  • HIV Infections / virology*
  • HLA-DR Antigens / immunology
  • Humans
  • Lymphocyte Activation / immunology*
  • Male
  • Middle Aged
  • Species Specificity

Substances

  • Biomarkers
  • DNA, Viral
  • HLA-DR Antigens
  • ADP-ribosyl Cyclase 1