Carrot juice fermented with Lactobacillus plantarum NCU116 ameliorates type 2 diabetes in rats

J Agric Food Chem. 2014 Dec 10;62(49):11884-91. doi: 10.1021/jf503681r. Epub 2014 Nov 26.

Abstract

The effect of carrot juice fermented with Lactobacillus plantarum NCU116 on high-fat and low-dose streptozotocin (STZ)-induced type 2 diabetes in rats was studied. Rats were randomly divided into five groups: non-diabetes mellitus (NDM), untreated diabetes mellitus (DM), DM plus L. plantarum NCU116 (NCU), DM plus fermented carrot juice with L. plantarum NCU116 (FCJ), and DM plus non-fermented carrot juice (NFCJ). Treatments of NCU and FCJ for 5 weeks were found to favorably regulate blood glucose, hormones, and lipid metabolism in the diabetic rats, accompanied by an increase in short-chain fatty acid (SCFA) in the colon. In addition, NCU and FCJ had restored the antioxidant capacity and morphology of the pancreas and kidney and upregulated mRNA of low-density lipoprotein (LDL) receptor, cholesterol 7α-hydroxylase (CYP7A1), glucose transporter-4 (GLUT-4), peroxisome proliferator-activated receptor-α (PPAR-α), and peroxisome proliferator-activated receptor-γ (PPAR-γ). These results have for the first time demonstrated that L. plantarum NCU116 and the fermented carrot juice had the potential ability to ameliorate type 2 diabetes in rats.

Keywords: Lactobacillus plantarum NCU116; antidiabetic effect; blood glucose; carrot juice; oxidative stress; type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Beverages / analysis
  • Beverages / microbiology*
  • Blood Glucose / metabolism
  • Cholesterol 7-alpha-Hydroxylase / metabolism
  • Daucus carota / metabolism
  • Daucus carota / microbiology*
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Fermentation
  • Glucose Transporter Type 4 / metabolism
  • Humans
  • Lactobacillus plantarum / metabolism*
  • Lipid Metabolism
  • Lipoproteins, LDL / metabolism
  • Male
  • PPAR alpha / metabolism
  • Rats
  • Rats, Wistar

Substances

  • Blood Glucose
  • Glucose Transporter Type 4
  • Lipoproteins, LDL
  • PPAR alpha
  • Cholesterol 7-alpha-Hydroxylase