Insect response to plant defensive protease inhibitors

Annu Rev Entomol. 2015 Jan 7;60:233-52. doi: 10.1146/annurev-ento-010814-020816. Epub 2014 Oct 17.

Abstract

Plant protease inhibitors (PIs) are natural plant defense proteins that inhibit proteases of invading insect herbivores. However, their anti-insect efficacy is determined not only by their potency toward a vulnerable insect system but also by the response of the insect to such a challenge. Through the long history of coevolution with their host plants, insects have developed sophisticated mechanisms to circumvent antinutritional effects of dietary challenges. Their response takes the form of changes in gene expression and the protein repertoire in cells lining the alimentary tract, the first line of defense. Research in insect digestive proteases has revealed the crucial roles they play in insect adaptation to plant PIs and has brought about a new appreciation of how phytophagous insects employ this group of molecules in both protein digestion and counterdefense. This review provides researchers in related fields an up-to-date summary of recent advances.

Keywords: adaptation; counterdefense; digestion; phytophagous insects; protease; transcription regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gastrointestinal Tract / enzymology
  • Gene Expression*
  • Herbivory
  • Insect Proteins / genetics*
  • Insect Proteins / metabolism
  • Insecta / enzymology
  • Insecta / genetics
  • Insecta / physiology*
  • Peptide Hydrolases / genetics*
  • Peptide Hydrolases / metabolism
  • Plant Proteins / metabolism*
  • Plants / metabolism*
  • Protease Inhibitors / metabolism*

Substances

  • Insect Proteins
  • Plant Proteins
  • Protease Inhibitors
  • Peptide Hydrolases