Cyclooxygenase Pathways

Acta Biochim Pol. 2014;61(4):639-49. Epub 2014 Oct 23.

Abstract

This review compiles the current knowledge on the effects of prostanoids - arachidonic acid metabolites - on their own synthesis, activity and degradation. Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A₂ and prostaglandin I₂ receptors. The questions of desensitization and internalization of receptors are discussed. The stages of the inflammatory response and tumor progression are analyzed against the background of the disruption of the synthesis of prostanoids. Special attention is given to the significance of 15-deoxy-Δ(12,14)-prostaglandin J₂ in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. Ultimately, therapeutic approaches as used in various treatments are discussed in the light of the available knowledge.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Prostaglandin D2 / analogs & derivatives
  • Prostaglandin D2 / metabolism
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Prostaglandins / metabolism
  • Receptors, Epoprostenol / metabolism
  • Receptors, Thromboxane A2, Prostaglandin H2 / metabolism

Substances

  • 15-deoxy-delta(12,14)-prostaglandin J2
  • Prostaglandins
  • Receptors, Epoprostenol
  • Receptors, Thromboxane A2, Prostaglandin H2
  • Prostaglandin-Endoperoxide Synthases
  • Prostaglandin D2