Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo-controlled trial

J Med Food. 2015 Mar;18(3):306-13. doi: 10.1089/jmf.2014.3160. Epub 2014 Oct 24.


This study was a randomized, double-blind placebo-controlled trial to assess the efficacy of 4 weeks of mulberry leaf aqueous extract (MLAE) supplementation (5 g/day) for postprandial glycemic control in 36 subjects with impaired fasting glucose (IFG) tolerance. Postprandial responses in the glucose, insulin, and C-peptide levels were measured after a carbohydrate load both at baseline and after 4 weeks of MLAE supplementation. The postprandial glycemic response was attenuated in the MLAE group after the treatment period, particularly 30 and 60 min after loading (P=.003 and 0.0325 for glucose, P=.0005 and .0350 for insulin, and P=.0151 and .0864 for C-peptide). Additionally, the incremental area under the curve for insulin was significantly lower in the MLAE group than in the placebo group (P=.0207). Four weeks of MLAE supplementation improved postprandial glycemic control in individuals with IFG tolerance.

Keywords: 1-deoxynojirimycin; mulberry leaf aqueous extract; postprandial glycemic control.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Biological Assay
  • Blood Glucose / metabolism*
  • C-Peptide / metabolism
  • Dietary Supplements
  • Double-Blind Method
  • Fasting
  • Female
  • Glucose Intolerance / blood
  • Glucose Intolerance / drug therapy*
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Insulin / blood*
  • Male
  • Middle Aged
  • Morus*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Leaves
  • Postprandial Period
  • Prediabetic State / blood
  • Prediabetic State / drug therapy*


  • Blood Glucose
  • C-Peptide
  • Hypoglycemic Agents
  • Insulin
  • Plant Extracts