Biomarkers in acute kidney injury: are we ready for prime time?

Nephron Clin Pract. 2014;127(1-4):176-9. doi: 10.1159/000363206. Epub 2014 Sep 24.

Abstract

Novel biomarkers are required to improve the timely detection of early acute kidney injury (AKI) and to improve the differential diagnosis, prognostic assessment, and management of AKI cases. It is anticipated that novel biomarkers of early structural AKI ('acute kidney damage') will provide critical diagnostic and prognostic stratification and complement functional markers such as serum creatinine. Further studies are required to conclusively demonstrate the association between early kidney damage biomarkers and clinical outcomes, both with and independently of functional markers, and to discern whether or not randomization to a treatment for AKI based on high structural/damage biomarker levels results in an improvement in kidney function and clinical outcomes.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / urine
  • Acute-Phase Proteins / urine
  • Biomarkers / analysis*
  • Biomarkers / blood
  • Biomarkers / urine
  • Creatinine / blood
  • Diagnosis, Differential
  • Early Diagnosis
  • Fatty Acid-Binding Proteins / urine
  • Hepatitis A Virus Cellular Receptor 1
  • Humans
  • Interleukin-18 / urine
  • Kidney Function Tests
  • Lipocalin-2
  • Lipocalins / blood
  • Lipocalins / urine
  • Membrane Glycoproteins / urine
  • Multicenter Studies as Topic
  • Proto-Oncogene Proteins / blood
  • Proto-Oncogene Proteins / urine
  • Receptors, Virus
  • Renal Insufficiency, Chronic / diagnosis

Substances

  • Acute-Phase Proteins
  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins
  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • IL18 protein, human
  • Interleukin-18
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Membrane Glycoproteins
  • Proto-Oncogene Proteins
  • Receptors, Virus
  • Creatinine