The effects of successful percutaneous mitral balloon valvuloplasty on acute and intermediate term aortic stiffness

Echocardiography. 2015 May;32(5):813-8. doi: 10.1111/echo.12799. Epub 2014 Oct 27.

Abstract

Aim: The aim of this study was to evaluate the effects of percutaneous mitral balloon valvuloplasty (PMBV) on short- and intermediate-term aortic stiffness in patients with mitral stenosis.

Materials and methods: This prospective study included 56 patients with critical mitral stenosis in normal sinus rhythm (68% female; mean age: 42 ± 11 years) and 37 healthy controls. Aortic stiffness was measured using transthoracic echocardiography before PMBV, and 24-48 hours and 1 year post procedure.

Results: Aortic strain and distensibility were significantly higher in the patients with mitral stenosis, both after PMBV and 1 year post procedure, whereas the aortic stiffness index (ASI) was significantly lower. There was also a significant decrease in mitral mean gradient (MMG) and systolic pulmonary artery pressure (sPAP) after PMBV, based on echocardiography and catheterization. Mitral valve area (MVA) significantly increased after PMBV. There was a significant correlation between change in ∆MVA and ∆MMG and aortic elastic properties. There was a significantly negative correlation between the ∆MVA and ∆∆ aortic stiffness (r = -0.62, P < 0.001), and a significantly positive correlation between ∆MMG and ∆ASI (r = 0.60, P < 0.001).

Conclusion: Mitral valve stenosis was associated with impaired aortic stiffness and following PMBV, aortic stiffness decreased during both the acute period and the intermediate period.

Keywords: mitral stenosis; percutaneous intervention; transthoracic echocardiography.

MeSH terms

  • Acute Disease
  • Adult
  • Aorta / diagnostic imaging
  • Aortic Diseases / complications*
  • Aortic Diseases / diagnostic imaging*
  • Aortic Diseases / physiopathology
  • Balloon Valvuloplasty*
  • Female
  • Humans
  • Male
  • Mitral Valve Stenosis / complications*
  • Mitral Valve Stenosis / diagnostic imaging
  • Mitral Valve Stenosis / physiopathology
  • Prospective Studies
  • Time Factors
  • Treatment Outcome
  • Ultrasonography
  • Vascular Stiffness / physiology*