[The biological evaluation of depression severity: a novel method for the determination of platelet serotonin concentration]

Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(8):51-7.
[Article in Russian]


Objective: To develop a highly sensitive method for the determination of platelet-rich plasma serotonin concentration for every-day clinical practice.

Material and methods: The method was developed for determination of serotonin in plateled-rich plasma. Serotonin was determined using high performance liquid chromatography with fluorescent detection and hematologic analyzer.

Results and conclusion: In healthy people, concentrations of platelet serotonin were similar to those reported in literature: from 2.19 to 4.87 nmol/109 platelets. In patients with depression (n=30), platelet serotonin concentrations were lower (from 0.11 to 2.89 nmol/109 platelets) and correlated with the severity of depression. The method may be used in clinical purposes.

Publication types

  • English Abstract

MeSH terms

  • Blood Platelets / chemistry*
  • Chromatography, High Pressure Liquid / methods
  • Depressive Disorder / blood*
  • Humans
  • Platelet Count
  • Serotonin / blood*
  • Severity of Illness Index*


  • Serotonin