[Interactions between the immune system and the neuroendocrine system. Implications of the hypothalamo-hypophyseal-adrenal axis]

Arch Neurobiol (Madr). 1989 Nov-Dec;52(6):277-86.
[Article in Spanish]


The immune and neuroendocrine systems are now recognized to be linked and involved in bidirectional communication. That interrelationship involves shared usage of common signal molecules and their receptors. The Immune System and its products can modulate neuroendocrine functions and neuroendocrine peptides and hormones can affect important immunological parameters. Specifically, this article review the evidence for immune-neuroendocrine interactions in relation to the Hypothalamic-Pituitary-Adrenocortical axis. Neuroendocrine-immune interactions appears to play an important role in psychosocial influences on immunologically resisted and mediated diseases.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Corticotropin-Releasing Hormone / biosynthesis
  • Corticotropin-Releasing Hormone / physiology
  • Glucocorticoids / physiology
  • Humans
  • Hypothalamo-Hypophyseal System / physiology*
  • Immune System / physiology*
  • Interleukin-1 / physiology
  • Lymphocytes / physiology
  • Pituitary-Adrenal System / physiology*
  • Stress, Psychological / physiopathology*
  • beta-Endorphin / biosynthesis
  • beta-Endorphin / physiology


  • Glucocorticoids
  • Interleukin-1
  • beta-Endorphin
  • Corticotropin-Releasing Hormone