Repeated ethanol exposure during early and late adolescence: double dissociation of effects on waiting and choice impulsivity

Alcohol Clin Exp Res. 2014 Oct;38(10):2579-89. doi: 10.1111/acer.12535.

Abstract

Background: A strong association exists between impulsivity and binge drinking, and between adolescent alcohol exposure and alcohol abuse in humans. To understand the extent to which early-life alcohol exposure contributes to increased impulsivity, we developed an animal model of binge drinking using 2 strains of mice, C57BL/6J (B6) and DBA2/J (D2), that differ in both motor impulsivity and alcohol drinking.

Methods: Mice were treated with 2 g/kg ethanol (EtOH) during their early (intermittent ethanol exposure [IEE]_Early; postnatal day [PND]30 to 45) or late (IEE_Late; PND45 to 60) adolescence or with saline (control group [CON]) throughout the adolescence period. To determine the consequences IEE on waiting impulsivity and attentional function, the number of premature responses and omissions, respectively, were evaluated in adulthood using the 5-choice serial reaction time task (5-CSRTT). To examine the effects of IEE on choice impulsivity, risky decision making was assessed in adulthood using a mouse version of the Iowa Gambling Task (mIGT). Additionally, the acute effects of EtOH in adulthood on waiting impulsivity and choice preference were investigated.

Results: We provide experimental evidence that IEE during late, but not early, adolescence disrupts waiting impulsivity and attentional abilities in the 5-CSRTT. In contrast, IEE during early, but not late, adolescence altered risky decision making in the mIGT. D2 mice consistently showed lower premature responding than B6 mice in both the mIGT and the 5-CSRTT, but greater risky decision making on the mIGT. IEE and CON mice showed similar responsiveness to the acute EtOH effects on premature responding, but increased risky choices only in B6_IEE_Early mice.

Conclusions: Our observations suggest a direct effect of IEE during adolescence on waiting and choice impulsivity and attention later in life.

Keywords: Adolescence; Ethanol; Impulsivity; Inbred Mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Animals
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology
  • Binge Drinking / physiopathology
  • Choice Behavior / drug effects*
  • Choice Behavior / physiology
  • Decision Making / drug effects
  • Decision Making / physiology
  • Dissociative Disorders / physiopathology*
  • Dose-Response Relationship, Drug
  • Ethanol / pharmacology*
  • Impulsive Behavior / drug effects*
  • Impulsive Behavior / physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Models, Animal
  • Species Specificity

Substances

  • Ethanol