Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans

Food Funct. 2015 Jan;6(1):204-10. doi: 10.1039/c4fo00697f. Epub 2014 Oct 27.


Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent energy intake in humans. Fifteen volunteers on three occasions were randomly offered a meal containing 30 g of bread and 30 mL of one of three selected oils: sunflower oil (SO), high oleic sunflower oil (HOSO) and virgin olive oil (VOO). Plasma EC concentrations and appetite ratings over 2 h and energy intake over 24 h following the experimental meal were measured. Results showed that after HOSO and VOO consumption the circulating oleoylethanolamide (OEA) was significantly higher than after SO consumption; a concomitantly significant reduction of energy intake was found. For the first time the oleic acid content of a meal was demonstrated to increase the post-prandial response of circulating OEA and to reduce energy intake at subsequent meals in humans.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Amides
  • Appetite Regulation*
  • Breakfast*
  • Cross-Over Studies
  • Diet Records
  • Endocannabinoids / blood*
  • Energy Intake*
  • Ethanolamines / blood
  • Female
  • Humans
  • Italy
  • Linoleic Acids / blood
  • Male
  • Oleic Acid / administration & dosage*
  • Oleic Acid / analysis
  • Oleic Acids / blood*
  • Olive Oil
  • Palmitic Acids / blood
  • Plant Oils / chemistry*
  • Polyunsaturated Alkamides / blood
  • Postprandial Period
  • Sunflower Oil
  • Young Adult


  • Amides
  • Endocannabinoids
  • Ethanolamines
  • Linoleic Acids
  • Oleic Acids
  • Olive Oil
  • Palmitic Acids
  • Plant Oils
  • Polyunsaturated Alkamides
  • Sunflower Oil
  • oleoylethanolamide
  • Oleic Acid
  • linoleoyl ethanolamide
  • palmidrol