Deep and quantitative top-down proteomics in clinical and translational research

Expert Rev Proteomics. 2014 Dec;11(6):649-51. doi: 10.1586/14789450.2014.976559. Epub 2014 Oct 28.


It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

Keywords: clinical; proteomics; quantitative; top-down; translational.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers / metabolism
  • Biomedical Research*
  • Humans
  • Mass Spectrometry / methods
  • Protein Processing, Post-Translational
  • Proteins / metabolism*
  • Proteolysis
  • Proteome / metabolism*
  • Proteomics


  • Biomarkers
  • Proteins
  • Proteome