Analytical tools and current challenges in the modern era of neuroepigenomics

Nat Neurosci. 2014 Nov;17(11):1476-90. doi: 10.1038/nn.3816. Epub 2014 Oct 28.


Over the past decade, rapid advances in epigenomics research have extensively characterized critical roles for chromatin regulatory events during normal periods of eukaryotic cell development and plasticity, as well as part of aberrant processes implicated in human disease. Application of such approaches to studies of the CNS, however, is more recent. Here we provide a comprehensive overview of available tools for analyzing neuroepigenomics data, as well as a discussion of pending challenges specific to the field of neuroscience. Integration of numerous unbiased genome-wide and proteomic approaches will be necessary to fully understand the neuroepigenome and the extraordinarily complex nature of the human brain. This will be critical to the development of future diagnostic and therapeutic strategies aimed at alleviating the vast array of heterogeneous and genetically distinct disorders of the CNS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Central Nervous System / metabolism*
  • Chromatin
  • Epigenomics*
  • Genome-Wide Association Study
  • Humans
  • Proteomics*
  • Statistics as Topic


  • Chromatin