Patients with scans without evidence of dopaminergic deficit: a long-term follow-up study

Mov Disord. 2014 Dec;29(14):1820-5. doi: 10.1002/mds.26018. Epub 2014 Oct 28.


Background: We previously reported on a cohort of dystonic tremor and patients with scans without evidence of dopaminergic deficit (SWEDDs). We aim to report the long-term clinical and imaging follow-up of these patients.

Patients and methods: Patients with at least 5-year follow-up were included. These patients had an asymmetric arm tremor, a previous diagnosis of Parkinson's disease (PD), and a subsequent normal DaTscan. The imaging and clinical follow-up was done on the clinical basis.

Results: Sixteen patients were included. The mean gap between the first and subsequent scans was 5.4 years. Two patients (12.5%) had reduced nigrostriatal uptake on follow-up DaTscan, whereas 14 continued to have normal dopaminergic imaging.

Conclusion: This is the longest follow up of patients with asymmetric rest tremor and normal DaT scans (SWEDDs) reported to date. We show here that only a minority of them show reduced striatonigral uptake over long term follow up.

Keywords: DaTscan; Parkinson's disease; SWEDD; dopamine; dystonia; dystonic tremor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins / metabolism*
  • Dystonic Disorders / diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis
  • Parkinson Disease / physiopathology*
  • Time
  • Tomography, Emission-Computed, Single-Photon / methods
  • Tremor / diagnosis


  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine