Human G3P[4] rotavirus obtained in Japan, 2013, possibly emerged through a human-equine rotavirus reassortment event

Virus Genes. 2015 Feb;50(1):129-33. doi: 10.1007/s11262-014-1135-z. Epub 2014 Oct 29.

Abstract

Two novel G3P[4] rotavirus strains were detected from children with acute diarrhea in Sendai, Japan, identified as a G3-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 genotype constellation by whole-genome sequence analysis. The VP7 gene of the two strains displayed the highest nucleotide sequence identity (91 %) and showed a close genetic relationship (99 % bootstrap value) to an equine rotavirus reported in India. The other gene segments were related to human group A rotaviruses. This report suggests a possible reassortment event between human and equine rotaviruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / genetics
  • Capsid Proteins / genetics
  • Child, Preschool
  • Cluster Analysis
  • Diarrhea / epidemiology
  • Diarrhea / virology
  • Female
  • Horses
  • Humans
  • Infant
  • Japan / epidemiology
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics*
  • Reassortant Viruses / genetics*
  • Reassortant Viruses / isolation & purification*
  • Rotavirus / genetics*
  • Rotavirus / isolation & purification*
  • Rotavirus Infections / epidemiology
  • Rotavirus Infections / virology*
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid

Substances

  • Antigens, Viral
  • Capsid Proteins
  • RNA, Viral
  • VP7 protein, Rotavirus

Associated data

  • GENBANK/KJ639012
  • GENBANK/KJ639013
  • GENBANK/KJ639014
  • GENBANK/KJ639015
  • GENBANK/KJ639016
  • GENBANK/KJ639017
  • GENBANK/KJ639018
  • GENBANK/KJ639019
  • GENBANK/KJ639020
  • GENBANK/KJ639021
  • GENBANK/KJ639022
  • GENBANK/KJ639023
  • GENBANK/KJ639024
  • GENBANK/KJ639025
  • GENBANK/KJ639026
  • GENBANK/KJ639027
  • GENBANK/KJ639028
  • GENBANK/KJ639029
  • GENBANK/KJ639030
  • GENBANK/KJ639031
  • GENBANK/KJ639032
  • GENBANK/KJ639033