Antibiotic-resistant gram-negative bacterial infections in patients with cancer

Clin Infect Dis. 2014 Nov 15;59 Suppl 5(Suppl 5):S335-9. doi: 10.1093/cid/ciu612.


Patients with cancer are at high risk for infections caused by antibiotic resistant gram-negative bacteria. In this review, we summarize trends among the major pathogens and clinical syndromes associated with antibiotic resistant gram-negative bacterial infection in patients with malignancy, with special attention to carbapenem and expanded-spectrum β-lactam resistance in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia--all major threats to our cancer patients. Optimal therapy for these antibiotic-resistant pathogens still remains to be determined.

Keywords: Acinetobacter baumannii; Pseudomonas aeruginosa; carbapenem-resistant Enterobacteriaceae; infections; neutropenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Acinetobacter baumannii / drug effects
  • Carbapenems / therapeutic use
  • Drug Resistance, Bacterial*
  • Escherichia coli / drug effects
  • Gram-Negative Bacterial Infections / complications
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Klebsiella pneumoniae / drug effects
  • Neoplasms / complications*
  • Pseudomonas aeruginosa / drug effects
  • Stenotrophomonas maltophilia / drug effects
  • beta-Lactamases / therapeutic use


  • Carbapenems
  • beta-Lactamases