The multiple roles of sGP in Ebola pathogenesis

Viral Immunol. 2015 Feb;28(1):3-9. doi: 10.1089/vim.2014.0068.


Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hemorrhagic Fever, Ebola / pathology*
  • Hemorrhagic Fever, Ebola / veterinary
  • Hemorrhagic Fever, Ebola / virology*
  • Humans
  • Viral Envelope Proteins / physiology*
  • Virulence Factors / physiology*


  • Viral Envelope Proteins
  • Virulence Factors
  • envelope glycoprotein, Ebola virus